Multiple candidates have begun announcing their campaigns for U.S. Senate seats in the 2026 midterm elections, setting the stage for competitive races across several states.

In South Carolina, Dr. Annie Andrews, a pediatrician, is mounting a Democratic challenge against incumbent Republican Senator Lindsey Graham. Andrews believes the longtime senator is vulnerable in his reelection bid.

Meanwhile, former Tennessee football head coach Derek Dooley has announced his intention to run for a U.S. Senate seat in Georgia's 2026 race. Dooley, transitioning from coaching to politics, has stated he plans to be "the last man standing" in the competitive primary field.

In Maine, incumbent Senator Susan Collins is preparing for reelection and will face Democratic challenger Graham Platner, described as a military veteran and oyster farmer. The Maine race is expected to be closely watched as a potentially competitive contest.

The 2026 midterm elections will feature 20 Senate seats up for election, with candidates from both parties beginning to position themselves for what could be pivotal races in determining control of the upper chamber. Early announcements typically signal the importance campaigns place on fundraising and building organizational support well ahead of the election cycle.