Texas Children's Hospital will establish the nation's first detransition clinic and pay $10 million to the state of Texas under a settlement announced Friday by Attorney General Ken Paxton.

The agreement requires the Houston-based hospital to create a clinic focused on providing medical care to patients who previously received gender-affirming healthcare and seek to reverse its effects. The hospital must also terminate five physicians as part of the settlement terms.

The settlement represents an unusual resolution between a state government and a major medical institution over gender-affirming care policies. Texas Children's Hospital is one of the largest pediatric medical centers in the United States.

Under the agreement, the proposed detransition clinic would provide services to individuals seeking to reverse previous gender transition treatments. The specific medical services and protocols for such a clinic have not been detailed in the announcement.

The settlement comes amid ongoing legal and political debates across multiple states regarding gender-affirming medical care for minors. Various state governments have implemented different policies and restrictions on such treatments in recent years.

Neither Texas Children's Hospital nor representatives for the terminated physicians have publicly responded to the settlement announcement. The timeline for establishing the detransition clinic has not been specified.