More than 160 environmental and public health organizations called Tuesday for Environmental Protection Agency Administrator Lee Zeldin to resign or be fired, citing concerns over the agency's direction under his leadership.

In an open letter, the groups accused Zeldin of abandoning the EPA's core mission to protect human health and the environment. The organizations alleged that under Zeldin's administration, the agency has rolled back environmental protections while reducing staff and funding levels.

Meanwhile, federal health agencies are experiencing significant personnel and operational changes. Dr. Robert Malone, who served as vice chair of a federal vaccine advisory committee, has resigned from his position. Malone had been appointed by Health and Human Services Secretary Robert F. Kennedy Jr. following changes to the committee's previous membership.

Senate Democrats have expressed concerns about disruptions to the U.S. Preventive Services Task Force, a panel that develops health care guidelines affecting coverage decisions for Americans. The health secretary has canceled or postponed three scheduled meetings of this committee, prompting criticism from Democratic lawmakers.

The Trump administration is also preparing to nominate a new director for the Centers for Disease Control and Prevention. Health experts have raised concerns about the selection process, with some emphasizing the need for qualified leadership rather than public figures primarily known for media appearances.

These developments reflect broader changes occurring across federal health and environmental agencies as the new administration implements its policy priorities and leadership appointments.